S. Ayaz¹, B.S. Güney²

¹Hematology Department of Turkey High Speciality Hospital, Ankara, Turkey, ²Dade-Behring, İstanbul,Turkey

Background: PVT is rare in intrahepatic cholangiocarcinoma (CC) and metastatic liver tumors (MLT), but common in HCC. Invasion of portal veins by hepatoma cells was considered as the main reason of PVT. To determine if there is any relation between coagulation disorders and PVT in HCC. Methods: Platelet counts, PT, aPTT, thrombin time (TT), fibrinogen, d- dimer, protein-C, protein-S, antithrombin, plasminogen, a-2 antiplasmin, coagulation factors (CF) 5, 7, 8, 9, 11 and 13, vWF, prothrombin fragment 1+2 (PF1+2), tPA and PAI- were studied in 11 patients with HCC (6 with PVT), 10 healthy control, 10 CC, 10 MLT, 10 cirrhosis with PVT and 43 cirrhosis without PVT (Child-Pugh Class: 13 A, 17 B, 13 C).Biochemical, blood count measurements and hemostatic, fibrinolytic factors and PF 1+2 level are measured with Hitachi 800 autoanalyzer( Roche Diagnostics, Germany), Coulter LH 750 Cell Blood Counter( Beckman Coulter, UK), automated coagulometer(BCS, Dade-Behring, Germany), and ELISA method( Dade-Behring, Germany). Results: Platelet, antithrombin, protein-C, plasminogen and CF 5, 7, 9, 11 and 13 levels of HCC group was lower and FT, aFTT, TT, vWF, PF1+2, tPA and PAI-1 levels was higher than control group. When compared with CC, fibrinogen, antithrombin, plasminogen and CF 5, 7, 8, 9 and 11 was lower in HCC and TT was higher. Similar differences were present between HCC and MLT groups. The results of Child-Pugh-B group were similar with HCC group. Protein-C,antithrombin, plasminogen and CF 5, 7 and 9 levels of HCC group were lower and tPA was higher than Child-Pugh-A group. Fibrinogen, antithrombin and CF 7 and 13 levels of Child-Pugh-C group were lower than HCC group and PT and aFTT levels were higher. The findings of cirrhosis patients having PVT were identical with the HCC patients. Conclusion: Coagulation abnormalities are related with PVT seen in HCC or cirrhosis